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The flesh of the wahoo is white, delicate, and highly regarded by many gourmets; indeed the Hawai'ian name for the fish, Ono, is also the Hawai'ian word for "tasty" or "delicious". This has created some demand for the wahoo as a premium priced commercial food fish. In many areas of its range, such as Hawaii, Bermuda and many parts of the Caribbean, local demand for wahoo is met by artisanal commercial fishermen, who take them primarily by trolling, as well as by recreational sports fishermen who sell their catch.
Although local wahoo populations can be affected by heavy commercial and sports fishing pressure, wahoo as a species are less susceptible to industrial commercial fishing than more tightly schooling and abundant species such as tuna. Wahoo are regularly taken as a by-catch in various commercial fisheries, including longline fisheries for tuna, billfish and dolphinfish (a.k.a. Mahi-mahi or dorado) and in tuna purse seine fisheries — especially in sets made around floating objects, which act as a focal point for a great deal of other marine life besides tuna — but the species as a whole is not considered overfished.
In most parts of its range, the wahoo is a highly prized sport fishing catch. It reaches a good size, is often available not too far from land, and is a very good fighter on light to medium tackle. It is known in sports fishing circles for the speed and strength of its first run. The aggressive habits and razor-sharp teeth of the wahoo can however be of considerable annoyance when targeting larger gamefish, as when tuna or Marlin fishing.

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